In jeder Himmelsrichtung gibt es hier etwas Schönes zu erleben. Wer Erholung sucht und sich gerne in der freien Natur bewegt, der ist in der Region Lüneburger Heide , gelegen zwischen Hamburg und Hannover , goldrichtig. Die Universitätsstadt Lüneburg lockt mit einem mittelalterlichen Stadtbild , vielfältigsten Einkaufsmöglichkeiten und einem wunderschönen Kurpark nach englischem Vorbild.
Sie haben ein eigenes Pferd? Dann bringen Sie es doch einfach mit! Das Hotel bietet ca. Naturpark Südheide, Naturschutzgebiet Lüneburger Heide, Ellerndorfer Wacholderheide — zahlreiche Heideflächen warten darauf von Ihnen entdeckt zu werden. Gelber feiner Sand, sattgrüne Kiefern, buntes Laub, geheimnisvolle Moorlandschaften — die Heidelandschaften bieten nicht nur spätsommerliche violette Blütenpracht. Am Ortsrand befindet sich das "Museum am Mühlenberg". In mehr als acht Gebäuden des Freilichtmuseums werden Arbeits- und Werkstätten unterschiedlichster Handwerksberufe präsentiert: Die Ausstellung dokumentiert auf beeindruckende Art und Weise den Wandel des Handwerks in den vergangenen hundert Jahren.
Cell Culture Supernates Effect of intensive multifactorial treatment on vascular progenitor cells in hypertensive patients Authors: Cell Culture Supernates Different patterns of inflammatory and angiogenic factors are associated with peritoneal small solute transport and peritoneal protein clearance in peritoneal dialysis patients Authors: D Ko, S Kim Oncotarget, ;9 1: Consequences for cognitive function in humans Authors: Cell Culture Supernates Matrix metalloproteinase is a biomarker of angiogenic activity in proliferative diabetic retinopathy Authors: A case-control study Authors: Serum Intravitreal injection of aflibercept, an anti-VEGF antagonist, down-regulates plasma von Willebrand factor in patients with age-related macular degeneration Authors: Plasma Physical Exercise and Spatial Training: Serum Induction of chemokine C-C motif ligand 5 by Epstein-Barr virus infection enhances tumor angiogenesis in nasopharyngeal carcinoma Authors: Cell Lysates The production method affects the efficacy of platelet derivatives to expand mesenchymal stromal cells in vitro Authors: Focus on Mast Cell Tryptase Authors: Serum Angiogenic T cell expansion correlates with severity of peripheral vascular damage in systemic sclerosis Authors: Serum Specific humoral and cellular immune responses in cancer patients undergoing chronic immunization with a VEGF-based therapeutic vaccine Authors: Serum Combination of the histone deacetylase inhibitor vorinostat with bevacizumab in patients with clear-cell renal cell carcinoma: Serum Prognostic impact of blood and urinary angiogenic factor levels at diagnosis and during treatment in patients with osteosarcoma: Serum Angiogenesis in newly regenerated bone by secretomes of human mesenchymal stem cells Authors: A Pilot Study Authors: Cell Culture Supernates Human and feline adipose-derived mesenchymal stem cells have comparable phenotype, immunomodulatory functions, and transcriptome Authors: Cell Culture Supernates Development and characterization of a human three-dimensional chondrosarcoma culture for in vitro drug testing Authors: Cell Culture Supernates Comparison of change in end tidal carbon dioxide after three minutes of step exercise between systemic sclerosis patients with and without pulmonary hypertension Authors: Elana J Bernstein Rheumatology Oxford , ;56 1: Biodegradable poly lactic acid-co-glycolic acid scaffolds as carriers for genetically-modified fibroblasts Authors: Cell Culture Supernates Expression of the angiogenic mediator, angiopoietin-like 4, in the eyes of patients with proliferative sickle retinopathy Authors: Aqueous and Vitreous Tetrahydrocurcumin induces mesenchymal-epithelial transition and suppresses angiogenesis by targeting HIF-1?
Cell Culture Supernates Improvement in asymmetric dimethylarginine and oxidative stress in patients with limb salvage after autologous mononuclear stem cell application for critical limb ischemia Authors: Cell Culture Supernates Genome surgery using Cas9 ribonucleoproteins for the treatment of age-related macular degeneration Authors: Pancreatic Fluid Evaluation of autologous skeletal muscle-derived factors for regenerative medicine applications Authors: Tissue Homogenates Phenformin has anti-tumorigenic effects in human ovarian cancer cells and in an orthotopic mouse model of serous ovarian cancer Authors: Cell Culture Supernates Ulcer healing effect of autologous mixed sheets consisting of fibroblasts and peripheral blood mononuclear cells in rabbit ischemic hind limb Authors: Serum Clinical usefulness of videocapillaroscopy and selected endothelial cell activation markers in people with Type 1 diabetes mellitus complicated by microangiopathy Authors: Cell Culture Supernates Characteristics of the specific humoral response in patients with advanced solid tumors after active immunotherapy with a VEGF vaccine, at different antigen doses and using two distinct adjuvants Authors: Serum C-X-C motif chemokine ligand 8 promotes endothelial cell homing via the Akt-signal transducer and activator of transcription pathway to accelerate healing of ischemic and hypoxic skin ulcers Authors: Cell Culture Supernates Profiling of cytokines, chemokines and other soluble proteins as a potential biomarker in colorectal cancer and polyps Authors: Serum CXCL1 is critical for pre-metastatic niche formation and metastasis in colorectal cancer Authors: Cell Culture Supernates Gestational diabetes mellitus is associated with increased pro-migratory activation of vascular endothelial growth factor receptor 2 and reduced expression of vascular endothelial growth factor receptor 1 Authors: A Randomized Controlled Trial Authors: Associations with Angiogenic Profiles Authors: Cell Culture Supernates Extracellular matrix nitration alters growth factor release and activates bioactive complement in human retinal pigment epithelial cells Authors: Cell Culture Supernates In smokers, Sonic hedgehog modulates pulmonary endothelial function through vascular endothelial growth factor Authors: Tissue Homogenates Motor neurons control blood vessel patterning in the developing spinal cord Authors: Further evidence from three randomized control trials Authors: Malcolm Kohler Respirology, ;0 C Wang Leukemia, ;0 Serum Human lung fibroblasts may modulate dendritic cell phenotype and function: Serum Overcoming the bottleneck of platelet lysate supply in large-scale clinical expansion of adipose-derived stem cells: A comparison of fresh versus three types of platelet lysates from outdated buffy coat-derived platelet concentrates Authors: Anne Fischer-Ni Cytotherapy, ;0 Cell Culture Supernates No effect of yeast-like fungi on lipid metabolism and vascular endothelial growth factor level in children and adolescents with type 1 diabetes mellitus Authors: Katarzyna Zorena Ital J Pediatr, ;42 1: Glenn Liu Cancer Chemother.
Asha M Das Oncoimmunology, ;5 Cell Culture Supernates Desflurane inhalation before ischemia increases ischemia-reperfusion-induced vascular leakage in isolated rabbit lungs Authors: Yoshiaki Oshima Springerplus, ;5 1: Rohit Bhatia Cerebrovasc Dis Extra, ;6 3: BiJun Wang Reproduction, ;0 Aspirated Follicle Fluid Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation, and protects from vascular damage in the retina EMBO Mol Med, ;0 Cell Culture Supernates A promising scaffold with excellent cytocompatibility and pro-angiogenesis action for dental tissue engineering: Strontium-doped calcium polyphosphate Authors: Tumor Extract Supernates Vascular endothelial growth factor A is associated with the subsequent development of moderate or severe cardiac allograft vasculopathy in pediatric heart transplant recipients Authors: David M Briscoe J.
Plasma Differential diagnosis of lung cancer, its metastasis and chronic obstructive pulmonary disease based on serum Vegf, Il-8 and MMP-9 Sci Rep, ;6 0: Plasma LXY - a novel manassantin A derivative - limits breast cancer growth through hypoxia-inducible factor-1 inhibition Onco Targets Ther, ;9 0: Whole Cells Cell therapy in critical limb ischemia: A comprehensive analysis of two cell therapy products Authors: Claire Tournois Cytotherapy, ;0 Cell Culture Supernates The anti-angiogenic and cytotoxic effects of the boswellic acid analog BA are potentiated by autophagy inhibitors.
Cell Culture Supernates Inhibition of placental growth factor in renal cell carcinoma. Cell Culture Supernates Anti-angiogenic pathway associations of the 3p Cell Culture Supernates In situ normoxia enhances survival and proliferation rate of human adipose tissue-derived stromal cells without increasing the risk of tumourigenesis. Serum Obstructive sleep apnoea syndrome, endothelial function and markers of endothelialization.
Serum VEGF in patients with advanced hepatocellular carcinoma receiving intra-arterial chemotherapy. Cell Culture Supernates Identification of tumour-reactive lymphatic endothelial cells capable of inducing progression of gastric cancer. Cell Culture Supernates Selecting bioactive phenolic compounds as potential agents to inhibit proliferation and VEGF expression in human ovarian cancer cells.
Intertumor heterogeneity in vascularity and invasiveness of artificial melanoma brain metastases. Cell Culture Supernates A randomized phase II study of capecitabine-based chemoradiation with or without bevacizumab in resectable locally advanced rectal cancer: Cell Culture Supernates Effects of a single intravitreal injection of aflibercept and ranibizumab on glomeruli of monkeys.
Plasma Heat shock protein 27 attenuates neointima formation and accelerates reendothelialization after arterial injury and stent implantation: Serum A novel splice variant of calcium and integrin-binding protein 1 mediates protein kinase D2-stimulated tumour growth by regulating angiogenesis.
Cell Culture Supernates Serum angiopoietin-2 and soluble VEGFR-2 levels predict malignancy of ovarian neoplasm and poor prognosis in epithelial ovarian cancer. Serum DeltaNp63 promotes pediatric neuroblastoma and osteosarcoma by regulating tumor angiogenesis.
Cell Culture Supernates Mobilization of circulating endothelial progenitor cells correlates with the clinical course of hantavirus disease. Cell Culture Supernates Effects of high intensity training and high volume training on endothelial microparticles and angiogenic growth factors. Serum Hepatitis C virus core protein induces hypoxia-inducible factor 1alpha-mediated vascular endothelial growth factor expression in Huh7.
Cell Culture Supernates Anticoagulation inhibits tumor cell-mediated release of platelet angiogenic proteins and diminishes platelet angiogenic response. Plasma Oestrogen-induced angiogenesis promotes adenomyosis by activating the Slug-VEGF axis in endometrial epithelial cells. Pathogen-free, plasma-poor platelet lysate and expansion of human mesenchymal stem cells. Cell Culture Supernates Endoplasmic reticulum ER stress and hypoxia response pathways interact to potentiate hypoxia-inducible factor 1 HIF-1 transcriptional activity on targets like vascular endothelial growth factor VEGF.
Role of RUNX3 in suppressing metastasis and angiogenesis of human prostate cancer. Cell Culture Supernates Effects of sFlt-1 and alpha 2-macroglobulin on vascular endothelial growth factor-induced endothelin-1 upregulation in human microvascular endothelial cells. Cell Culture Supernates COX-2 silencing enhances tamoxifen antitumor activity in breast cancer in vivo and in vitro. Cell Culture Supernates Evaluation of a new recombinant oncolytic vaccinia virus strain GLV-5b for feline mammary carcinoma therapy.
Cell Culture Supernates Effects of pitavastatin versus atorvastatin on the peripheral endothelial progenitor cells and vascular endothelial growth factor in high-risk patients: Serum Gene electro transfer of plasmid encoding vascular endothelial growth factor for enhanced expression and perfusion in the ischemic swine heart.
Tissue Homogenates Analysis of plasma cytokines and angiogenic factors in patients with pretreated urothelial cancer receiving Pazopanib: Plasma A method to assess target gene involvement in angiogenesis in vitro and in vivo using lentiviral vectors expressing shRNA.
Cell Culture Supernates WNT5A induces release of exosomes containing pro-angiogenic and immunosuppressive factors from malignant melanoma cells.
Cell Culture Supernates Ex vivo expansion of bovine corneal endothelial cells in xeno-free medium supplemented with platelet releasate.
Cell Culture Supernates Molecular patterns in deficient mismatch repair colorectal tumours: Tissue Homogenates Interferon-beta inhibits glioma angiogenesis through downregulation of vascular endothelial growth factor and upregulation of interferon inducible protein Cell Lysates RUNX3 inhibits hypoxia-inducible factor-1alpha protein stability by interacting with prolyl hydroxylases in gastric cancer cells.
Whole Cells alpha6-Integrin is required for the adhesion and vasculogenic potential of hemangioma stem cells. Cell Culture Supernates Metabolic impact of anti-angiogenic agents on U87 glioma cells. Cell Culture Supernates Surgical sutures filled with adipose-derived stem cells promote wound healing. Cell Culture Supernates A synthetic dl-nordihydroguaiaretic acid Nordy , inhibits angiogenesis, invasion and proliferation of glioma stem cells within a zebrafish xenotransplantation model.
Cell Culture Supernates Local acting Sticky-trap inhibits vascular endothelial growth factor dependent pathological angiogenesis in the eye. Cell Culture Supernates Reduction of maternal circulating endothelial progenitor cells in human pregnancies with intrauterine growth restriction. Plasma Interleukin 4, interleukin 6 and osteopontin-serological markers of head and neck malignancy in primary diagnostics: Serum Long-term survival and biomarker correlates of tasquinimod efficacy in a multicenter randomized study of men with minimally symptomatic metastatic castration-resistant prostate cancer.
Plasma Detection of rapalog-mediated therapeutic response in renal cancer xenografts using 6 4 Cu-bevacizumab immunoPET. Cell Culture Supernates Inhibitory effect of baicalin and baicalein on ovarian cancer cells. Cell Culture Supernates Study of the quantitative, functional, cytogenetic, and immunoregulatory properties of bone marrow mesenchymal stem cells in patients with B-cell chronic lymphocytic leukemia.
Cell Culture Supernates Clinical outcome, proteome kinetics and angiogenic factors in serum after thermoablation of colorectal liver metastases. Serum Caspase 3 involves in neuroplasticity, microglial activation and neurogenesis in the mice hippocampus after intracerebral injection of kainic acid.
Cell Culture Supernates Subcellular localization and mechanism of secretion of vascular endothelial growth factor in human skeletal muscle. Dialysate Evidences of early senescence in multiple myeloma bone marrow mesenchymal stromal cells. Cell Lysates Selective blockade of matrix metalloprotease with a monoclonal antibody abrogates invasion, angiogenesis, and tumor growth in ovarian cancer.
Cell Culture Supernates Dasatinib plus capecitabine for advanced breast cancer: Plasma The mechanism through which octreotide inhibits hepatic stellate cell activity. Cell Culture Supernates Effect of platelet lysate on human cells involved in different phases of wound healing. Cell Culture Supernates Angiogenic and vasculogenic factors in the vitreous from patients with proliferative diabetic retinopathy. Vitreous Humor Dose selection trial of metronomic oral vinorelbine monotherapy in patients with metastatic cancer: Cell Culture Supernates Combination of albendazole and 2-methoxyestradiol significantly improves the survival of HCT tumor-bearing nude mice.
Plasma A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis.
Cell Culture Supernates Designing nanotopographical density of extracellular matrix for controlled morphology and function of human mesenchymal stem cells. At the turn of the 20th century, Friedrich was rediscovered by the Norwegian art historian Andreas Aubert — , whose writing initiated modern Friedrich scholarship,  and by the Symbolist painters, who valued his visionary and allegorical landscapes.
The Norwegian Symbolist Edvard Munch — would have seen Friedrich's work during a visit to Berlin in the s. Munch's print The Lonely Ones echoes Friedrich's Rückenfigur back figure , although in Munch's work the focus has shifted away from the broad landscape and toward the sense of dislocation between the two melancholy figures in the foreground.
Friedrich's landscapes exercised a strong influence on the work of German artist Max Ernst — , and as a result other Surrealists came to view Friedrich as a precursor to their movement. According to Rosenblum, "Rothko, like Friedrich and Turner, places us on the threshold of those shapeless infinities discussed by the aestheticians of the Sublime. The tiny monk in the Friedrich and the fisher in the Turner establish a poignant contrast between the infinite vastness of a pantheistic God and the infinite smallness of His creatures.
In the abstract language of Rothko, such literal detail—a bridge of empathy between the real spectator and the presentation of a transcendental landscape—is no longer necessary; we ourselves are the monk before the sea, standing silently and contemplatively before these huge and soundless pictures as if we were looking at a sunset or a moonlit night.
The contemporary artist Christiane Pooley gets inspired by Friedrich's work for her landscapes reinterpreting the history of Chile. Until , and especially after his friends had died, Friedrich's work lay in near-oblivion for decades. Yet, by , the symbolism in his work began to ring true with the artistic mood of the day, especially in central Europe. However, despite a renewed interest and an acknowledgment of his originality, his lack of regard for "painterly effect" and thinly rendered surfaces jarred with the theories of the time.
During the s, Friedrich's work was used in the promotion of Nazi ideology,  which attempted to fit the Romantic artist within the nationalistic Blut und Boden.
His reliance on symbolism and the fact that his work fell outside the narrow definitions of modernism contributed to his fall from favour. In , art historian Kenneth Clark wrote that Friedrich "worked in the frigid technique of his time, which could hardly inspire a school of modern painting", and suggested that the artist was trying to express in painting what is best left to poetry.
Friedrich's reputation suffered further damage when his imagery was adopted by a number of Hollywood directors, such as Walt Disney , built on the work of such German cinema masters as Fritz Lang and F.
Murnau , within the horror and fantasy genres. Today, his international reputation is well established. He is a national icon in his native Germany, and highly regarded by art historians and art connoisseurs across the Western World. He is generally viewed as a figure of great psychological complexity, and according to Vaughan, "a believer who struggled with doubt, a celebrator of beauty haunted by darkness.
In the end, he transcends interpretation, reaching across cultures through the compelling appeal of his imagery. He has truly emerged as a butterfly—hopefully one that will never again disappear from our sight". Friedrich was a prolific artist who produced more than attributed works. It is likely that some of today's more literal titles, such as The Stages of Life , were not given by the artist himself, but were instead adopted during one of the revivals of interest in Friedrich.
He kept a carefully detailed notebook on his output, however, which has been used by scholars to tie paintings to their completion dates. Old Heroes' Graves, , A dilapidated monument inscribed " Arminius " invokes the Germanic chieftain, a symbol of nationalism, while the four tombs of fallen heroes are slightly ajar, freeing their spirits for eternity.
Schloss Charlottenburg , Berlin. This painting marked a move away by Friedrich from depictions in broad daylight, and a return to nocturnal scenes, twilight and a deeper poignancy of mood. Moonrise over the Sea Alte Nationalgalerie , Berlin. During the early s, human figures appear with increasing frequency in his paintings. Of this period, Linda Siegel writes, "the importance of human life, particularly his family, now occupies his thoughts more and more, and his friends appear as frequent subjects in his art.
Graveyard under Snow Museum der bildenden Künste , Leipzig. Friedrich sketched memorial monuments and sculptures for mausoleums, reflecting his obsession with death and the afterlife. He also created some of the funerary art in Dresden's cemeteries. The Oak Tree in the Snow Friedrich was one of the first artists to portray winter landscapes as stark and dead.
His winter scenes are solemn and still—according to the art historian Hermann Beenken, Friedrich painted winter scenes in which "no man has yet set his foot". The Stages of Life Die Lebensstufen Museum der Bildenden Künste, Leipzig. The Stages of Life is a meditation on the artist's own mortality, depicting five ships at various distances from the shore. The foreground similarly shows five figures at different stages of life.
The Giant Mountains — Friedrich sought not just to explore the blissful enjoyment of a beautiful view, as in the classic conception, but rather to examine an instant of sublimity, a reunion with the spiritual self through the contemplation of nature. Seashore by Moonlight — His final "black painting", Seashore by Moonlight , is described by William Vaughan as the "darkest of all his shorelines. From Wikipedia, the free encyclopedia. German Romantic landscape painter — List of works by Caspar David Friedrich.
Spring , "Anxiety and Abstraction: Napoleon occupied the territory in , and in all of Pomerania passed to Prussian sovereignty. Archived from the original on 24 April Retrieved 13 January Caspar David Friedrich and the Subject of Landscape.
New Haven and London: His Life and Work. German Library of Information, Retrieved on 22 October Originally from Vaughan He exclaimed to Carus in , "Friedrich!
The only landscape painter so far to succeed in stirring up all the forces of my soul, the painter who has created a new genre: Cordula Grewe on Caspar David Friedrich". Artforum International , Vol. Oxford University Press, pp. Light for a Cold Land: Lawren Harris's Life and Work. Romantic Allegory and C. Friedrich", Studies in Romanticism , 28 1: The Guardian , January 15, Retrieved on November 20, But anyone who knew only this side of Friedrich's personality, namely his deep melancholic seriousness, only knew half the man.
I have met few people who have such a gift for telling jokes and such a sense of fun as he did, providing that he was in the company of people he liked. The Atlantic Times Germany , May Retrieved on 27 November Siegel , pp.